Curcuma Longa ameliorates hemodynamic indices in patients with acute coronary syndrome

Acute coronary syndrome, the most common form of heart disease, is the main cause of disability and death. It impairs the hemodynamic indices, leading to endangering the patients' condition. Curcuma Longa modulates blood pressure, breathing parameters, and temperature. The present study aimed to investigate the possible protective effects of Curcuma Longa on hemodynamic indices in acute coronary syndrome patients.

In this triple-blind clinical trial, 270 patients with acute coronary syndrome from the Coronary Care Unit in Kowsar Hospital in Semnan were included in the study from December 2019 to March 2021. Then, they were randomly divided into three groups, including the sham, intervention, and control groups (n=90). The intervention group received 500 mg of Curcuma Longa tablets. The sham group received 500 mg starch, Oisel, and lactose tablets. Drugs were administrated at 9 am, soon after breakfast, for 3 days. The control group received only the routine interventions. Before and 30 min after the intervention, the hemodynamic indices were recorded on 3 consecutive days using hemodynamic monitoring equipment (Pouyandegan Rah Saadat).

The average heart rate was significantly decreased in the intervention group than in the sham group (P=0.001 for day 1), (P<0.001 for day 2), and (P<0.001 for day 3). The average heart rate was significantly decreased in the intervention group than in the control group on the 2nd and 3rd days (P<0.001). Systolic and diastolic blood pressure were significantly decreased in the intervention group than in the sham, and control groups (P<0.001). Arterial blood oxygen saturation was significantly increased in the intervention group than in the sham and control groups (P<0.001).

Curcuma Longa reduces pulse rate, as well as systolic and diastolic blood pressure, and enhances arterial blood oxygen saturation in a triple-blind clinical trial study. The protective effects of Curcuma Longa on hemodynamic indices may highlight the use of this simple and affordable intervention in Coronary Care Units.