Synthesis and characterization of new 4,6-dimethoxy-1H-indole derivatives as antibacterial and antitumor agents

Article Type:
Research/Original Article (دارای رتبه معتبر)
New heterocyclic compounds derived from 4,6-Dimethoxy-1H-indole were synthesized. 4,6-Dimethoxy-1H-indole was reacted with chloroacetic acid to produce compound (R1) which used as starting material to synthesized  pyrazole, isoxazole, and pyrimidine derivatives respectively. Compound (R1) reacted with urea and  thiourea to produce diazetidin-2-one (R2) and diazetidine-2-thione (R3). On the other hand, (R1) was combined with thiosemecabazide to produce thiadiazole (R4) which combined with benzaldehyde in acetic acid to yield Schiff base compound (R5). This compound used as starting material to creation compounds (R6-R11) via reaction with hydrazine hydrate, phenyl hydrazine, hydroxylamine hydrochloride, acetamide, urea, and thiourea respectively. Anticancer and antibacterial activity of the synthesized compounds was investigated with good results. Compounds R3, R6, R9 and R11 with (NH) group demonstrated strong activity against MCF7 cells, the IC50 values range between 31.06 - 51.23 µg/mL.
Eurasian Chemical Communications, Volume:5 Issue: 5, May 2023
411 to 424  
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