The Possible Anti-nociceptive Effect of Troxerutin and Neural Interactions Using Formalin and Writhing Tests in Mice

Message:
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background

 Previous reports suggest flavonoids as potent analgesic compounds.

Objectives

 Based on these observations, the present study investigated the anti-nociceptive action of troxerutin and neural interactions with opioidergic, serotoninergic, and nitrergic systems in mice.

Methods

 A total of 340 male mice were randomly divided into 2 categories. Each category included four experiments with four groups. In the first experiment of formalin examination, the animals intraperitoneally received saline and troxerutin (50, 150, and 300 mg/kg). In the second experiment, the animals received saline, naloxone (2 mg/kg), troxerutin (300 mg/kg), and troxerutin+naloxone. In the third and fourth experiments, L-NAME (L-NG-Nitroarginine methyl ester) and cyproheptadine were injected. In this test, formalin was injected and paw licking time (pain sense) was recorded. In the writhing test, experimental groups were treated similarly and the mice were injected with acetic acid. Then, the inhibition of the writhing movements was recorded.

Results

 According to the findings, troxerutin decreased pain in the formalin test and writhing movements in the writhing test (P=0.001). Naloxone and troxerutin decreased licking time and writhing movements (P=0.001). L-NAME+troxerutin significantly diminished the anti-nociceptive effect of troxerutin on paw licking and inhibited pain response (P=0.001).

Conclusion

 These results suggested that troxerutin decreases inflammatory pain in mice, and this effect is mediated by opioidergic and nitrergic systems.

Language:
English
Published:
Avicenna Journal of Medical Biochemistry, Volume:11 Issue: 1, Jun 2023
Pages:
66 to 71
magiran.com/p2595373  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 1,390,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!