Two Centers Affiliated to Shiraz University of Medical Sciences

Colonoscopy is the main method of colon examination. Acceptable bowel preparation plays an effective role in examining the bowel. Diagnosis and treatment of colon polyps or non-bulging lesions such as vascular malformations and serrated polyps depend on the degree of intestinal cleanliness at the time of assessment. On the other hand, insufficient preparation makes the evaluation more difficult, the evaluation is incomplete, increases the time of colonoscopy and the need to repeat the procedure, and this increases the cost. Therefore, the purpose of the present study was to determine and prepare the large intestine for colonoscopy with pidrolox produced in Iran with and without Senagraf syrup in two centers affiliated to Shiraz University of Medical Sciences.

In the present prospective, double-blind descriptive study conducted in 2016 on 273 patients in need of non-emergency colonoscopy referred to Shahid Motahari and Shahid Faqihi clinics of Shiraz, Iran, 227 patients were randomly selected into two drug (111) and control groups. (116) were categorized and studied. The effect of adding Senagraf to pidrolox manufactured in Iran with pidrolox along with placebo on the level of intestinal readiness (based on Ottawa scoring) in eligible patients (20-78 years old) who were willing to enter the study was investigated and compared. Collected data were analyzed using Mann-Whitney, Kruskal-Wallis and Chi-square statistical tests.

The average score of intestinal cleanliness in whole and as well by different parts, in the drug group, was lower than the control group, which confirms better preparation (p=0.001). Compared to older people, younger people had cleaner intestines (p=0.001). The level of bowel preparation in female patients was also better than male patients (p=0.001). The travel time from the rectum to the cecum and the return time from the cecum to the rectum were significantly less than the control group (p=0.001). No significant side effects were observed in both groups.

Adding senna to Iranian polyethylene glycol (PEG) before colonoscopy increased bowel preparation and reduces colonoscopy time, without causing additional side effects.