Investigation of Serum PIVKA-II Levels in Patients with Helicobacter pylori Infection and Normal Group

Article Type:
Research/Original Article (دارای رتبه معتبر)

Helicobacter pylori is one of the most common microorganisms known in humans, and as a risk factor it can result in gastric cancer, therefore we decided to evaluate the serum level of PIVKA-II in patients with Helicobacter pylori (H. pylori) infection and normal group.

Materials and Methods

This study was performed on 90 patients (45 patients with H. pylori infection and 45 patients in the control group). After recording demographic information, serum level of PIVKA-II was measured in two groups by ELISA method.


The findings of our study showed no significant difference between the serum level of PIVKA-II in patients with H. pylori compared to those without infection (p = 0.08) but at the age of less than 40 years, the mean serum level of PIVKA-II in patients with H. pylori was significantly lower than the control group (p = 0.026), Also in men infected by H. pylori the mean serum level of PIVKA-II was significantly less than the control group. (p = 0.04)


The results of the present study indicate that the serum level of PIVKA-II in infected men as well as in people under 40 years of age with H. pylori infection, was significantly lower than the control group. Also, serum PIVKA-II levels in patients were significantly lower in men than women and in those under 40 years of age compared with those over 40 years of age.

Iranian Journal of Colorectal Research, Volume:11 Issue: 2, Jun 2023
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