THE EFFECT OF SODIUM BUTYRATE AND AEROBIC EXERCISE WITH TREADMILL, ALONE OR IN COMBINATION, ON BODY WEIGHT AND GLYCEMIC PARAMETERS IN DIABETIC RATS WITH HIGH-FAT-STREPTOZOTOCIN DIET

Type 2 diabetic mellitus is a popular metabolic disorder affecting enormous population around the world. The present study aimed to find out the effectiveness of sodium butyrate (NaB) and treadmill exercise on body weight and glycemic parameters in an experimental model of type 2 diabetes.

Thirty-five male Wistar rats were divided into 5 groups of control, diabetes, diabetes+sodium butyrate, diabetes+exercise, and diabetes+sodium butyrate+exercise. Type 2 diabetes was induced through 4 weeks of high-fat diet and then streptozotocin injection. Diabetic rats were treated with NaB (400 mg/kg daily) and treadmill exercise (5 days per week) for 6 weeks. Body weight and glycemic parameters such as fasting blood sugar, glucose tolerance, insulin level, insulin resistance index, and insulin sensitivity were evaluated in them.

The results of this study showed that sodium butyrate combined with treadmill exercise causes a significant increase in body weight compared to the diabetic group (p < 0.05). Also, the blood glucose level significantly decreased in sodium butyrate (p < 0.05), exercise (p < 0.01) and sodium butyrate+exercise (p < 0.001) groups compared to the diabetes group. The level of blood sugar in the glucose tolerance test significantly decreased in sodium butyrate (p < 0.05), exercise (p < 0.01), and sodium butyrate+exercise (p < 0.001) groups compared to the diabetes group. In the sodium butyrate+exercise group, a significant increase in insulin (p < 0.05) and insulin sensitivity (p < 0.05) was observed. Also, although insulin resistance was reduced in the sodium butyrate+exercise group compared to the diabetes group, this reduction was not significant (p > 0.05).

Sodium butyrate combined with exercise can improve body weight and glycemic parameters in type 2 diabetes patients.