Comparative study of tissue-eosinophils frequency in common oral reactive lesions
Soft tissue reactive lesions are the most common oral lesions. Eosinophils are leukocytes with multiple functions, which are considered to have multiple roles including angiogenesis and fibrogenesis. Considering the importance of reactive lesions and their prevalence in the Iranian population, this study attempts to investigate the role of eosinophils in the formation of common reactive lesions of the oral cavity.
In this cross-sectional descriptive-analytical study, 26 case of pyogenic granuloma, 27 case of irritation fibroma and 27 case of peripheral ossifying fibroma were selected from the archive of the Oral Pathology Department of Isfahan Dental School, which were prepared by excisional biopsy method. Clinical information including age, gender and location of the lesion was extracted. Congo red staining was performed and the number of eosinophil was counted. All data was entered into SPSS24 software and was statistically analyzed by Chi-square, Fisher's exact and Mann-Whitney tests. P<0.05 was considered as a significant difference.
The highest mean number of eosinophils was counted in pyogenic granuloma (24.88±32.08) and the lowest was counted in irritiation fibroma (10.11±23.22). According to the Kruskal-Wallis test, there was a significant difference in the average number of eosinophils (P = 0.001)
The number of eosinophils in the studied lesions, especially pyogenic granuloma is noticeable and can play a role in the pathogenesis of these lesions.
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