The response of the coagulation system and fibrinolytic factors to exercise and saffron: A systematic review

Article Type:
Review Article (دارای رتبه معتبر)

Blood coagulation is an important physiological process in maintaining homeostasis that causes blood to clot. The two main components of the hemostasis process are fibrinolysis and coagulation and influenced by many factors including physical activity and diet. This study aims to evaluate systematic review on the response of the coagulation system and Fibrolytic Factors to Exercise and Saffron.

Materials and Methods

Search for studies on the response of coagulation and fibrinolytic factors to exercise and saffron extract in the reputable databases Springer, Hindawi, PubMed, Google Scholar, Scopus, SID and ISC using the keyword Exercise Training and Saffron, platelet count (plt), fibrinogen level, relative activated thromboplastin time (PTT) and prothrombin time (PT) and plasminogen inhibitor-activating antigen (PAI-1), activating antigen tissue plasminogen (tPA), tPA activity and D-dimer were performed.


In studies related to saffron extract, its beneficial effects were observed during long-term interventions. However, saffron consumption during the short-term had no effect on coagulation factors. Also, in short-term aerobic and resistance training studies, some studies reported a transient improvement in coagulation indices. Both long-term aerobic and resistance training help to maintain of coagulation homeostasis.


Exercise and saffron and its effective substances on the coagulation and fibrinolysis processes in healthy people and in some diseases (such as myocardial infarction and diabetes) have benefits.

Journal of Basic Research in Medical Sciences, Volume:10 Issue: 1, Winter 2023
49 to 58  
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