Preparation, characterization and determination of antibacterial effects of zeolitic imidazolium frameworks coated by hyaluronic acid against methicillin-resistant Staphylococcus,, Pseudomonas aeruginosa, and Escherichia coli bacterial strains

Antibiotic resistance remain a major health challenge that threatens the lives of many people. Recent studies shows that metal nanoparticles, including zeolitic imidazolate frameworks, have good antibacterial properties. In this project, we attempted to synthesize a microporous nanoparticle called ZIF-8 (a subset of a large family of zeolitic imidazolate frameworks) and then functionalized it with silver and hyaluronic acid. It was found that such functionalization could improve antibacterial properties ZIF-8. ZIF-8 and ZIF-8/Ag@ZIF-8 were characterized thorough N2 adsorption-desorption analysis, Fourier transform infrared (FT-IR) spectroscopy, powder X-ray diffraction (PXRD), and scanning electron microscope (SEM). antibacterial properties ZIF-8 and ZIF-8/Ag@ZIF-8 against Methicillin-Resistant Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli was assessed by method of Microbroth dilution. Results demonstrated coating of ZIF-8 with Ag and HA could significantly improve antibacterial properties ZIF-8 against Methicillin-Resistant Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli . We believe that our findings demonstrate that the use of functionalized zeolitic imidazolate frameworks can be as excellent alternative candidates against bacterial infections.