Antimicrobial Activity of Lupeol and β-Amyrin (Triterpenoids) Isolated from the Rhizome of Dolichos pachyrhizus Harm
Message:
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Dolichos pachyrhizus (Annonaceae) has been traditionally used in Africa to treat syphilis and many other microbial infections. However, no phytochemical study and antimicrobial investigations have been conducted on this species. Thus there is need for the discovery and development of new antibiotics and anifungal. The triterpenoids [Lupeol (1) and β-amyrin (2)] isolated from rhizome of Dolichos pachyrhizus (Harm) were evaluated for their antimicrobial activity against some selected Gram positive bacterial, Gram negative bacterial and Fungal isolates. The antimicrobial activity of the crude extract and compounds isolated was determined using agar well diffusion method. The compounds exhibited antimicrobial activity against most of the tested bacteria with minimum inhibitory concentration (MIC) and minimum bactericidal/fungicidal concentrations (MBC/MFC) values ranging from 2.5 to 20 mg/ml and 5 to 40 mg/ml, respectively. The triterpenoids could be a potentially effective antimicrobial agent to combat infectious diseases. The structures of the compounds were elucidated using modern spectroscopic and spectrometric techniques such as nuclear magnetic resonance (NMR) and mass spectrometry (MS) to be Lupeol and β-amyrin.
Language:
English
Published:
Advanced Journal of Chemistry, Section A, Volume:7 Issue: 1, Winter 2024
Pages:
1 to 14
magiran.com/p2640056  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!