A novel approach for total synthesis of Stemona alkaloid: Tuberostemonamide

Message:
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:

Stemona alkaloids, are structurally complex and polycyclic alkaloids, obtained from a novel class of natural plants which are extracted, separated, and purified from Stemonaceae family. They are abundantly and more exclusively obtained from the renowned three classes namely: Stemona, Stichoneuron, and Croomia of monocotyledonous family Stemonaceae. They are structurally distinguished by the presence of a central pyrroloazepine core. By 2019, almost 215 Stemona alkaloids were isolated from nature. More than 80 members already discovered and many more are in pipeline likely to be isolated. Traditionally, their roots have been used for centuries in Chinese medicine for a variety of purposes including (but not limited to): treatment of bronchitis, tuberculosis, pertussis, as well as anti-parasitic agents. By rational comparing and contrasting, the multidimensional bioactivities of Stemona alkaloids specifically stemofoline-type derivatives are the most promising compounds representing many lead structures for further development of commercial agents used in pharmaceutical and chemical industries. Here, to this our total synthesis proposal, we vividly explained step by step the total synthesis procedure to get the Stemona alkaloid: Tuberostemonamide. This renowned Stemona alkaloid has potent pharmaceutical effects in the treatment of different neurodegenerative diseases and inflammatory conditions. For such fascinating future work and robust research scope, we interested to propose and work on a unique and effective total synthetic pathway for the Tuberostemonamide synthesis which can be used in synthetic organic lab. We believe our proposed synthetic process discussed here would be utilized efficiently and give highest possible yield (%).

Language:
English
Published:
Journal of Applied Organometallic Chemistry, Volume:1 Issue: 4, Oct 2021
Pages:
159 to 164
magiran.com/p2641549  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 1,390,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!