Comparing the Effectiveness and Complications of Sodae and Sodium Valproate on Migraine

Article Type:
Research/Original Article (دارای رتبه معتبر)

Sodium valproate is recommended as a first-line drug to prevent migraine attacks, and sodae is an herbal medicine.


Sodium valproate and herbal sodae were compared for effectiveness and side effects.

Materials & Methods

A two-center, randomized, double-blind clinical trial included migraine patients from Kermanshah and Hamadan cities into two groups: Sodae herbal recipients and valproate (200 mg) recipients, for 3 months. A numerical rating scale (NRS) scale was used to measure residual pain at the end of each month of treatment. Also, a researcher-made form and the headache impact test (HIT-6) questionnaire were used. Side effects reported by the patients were collected, and liver function tests and complete blood cell count tests were conducted.


A total of 70 migraine patients were evaluated: 33 patients (47%) in the soda group and 37 patients (53%) in the valproate group. The NRS scores in both groups decreased constantly, with no significant difference (P=0.303). Also, HIT-6 scores were constantly reduced in both groups with no significant difference (P>0.05). More side effects are significantly (P=0.043) reported in the valproate group (54.05%) than in the sodae group (30.30%). The most common side effect in the valproate group was drowsiness (13.5%), while among the sodae group, it was diarrhea (15.1%).


The sodae and valproate did not differ in headache improvement, HIT-6 scores, and changes in laboratory parameters. However, the valproate group reported more side effects than the sodae group. Sodae is a suitable herbal medicine for preventing and controlling migraine attacks.

Caspian Journal of Neurological Sciences, Volume:9 Issue: 35, Oct 2023
220 to 228  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 1,390,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required

Personal subscription
Subscribe for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!