Investigating the Association between rs4986790 Polymorphism of TLR4 Gene and Chronic Periodontitis in an Iranian Population

Article Type:
Research/Original Article (دارای رتبه معتبر)


Periodontitis is a multifactorial disease in terms of etiology, including microbial, environmental, systemic, and genetic factors, and the host's immune response causes periodontal destruction. The present study was done to investigate the association between rs4986790 polymorphism of the TLR4 gene with chronic periodontitis in an Iranian population.


The present case-control study was conducted on 120 people, including two groups of control (n=66) and patient (n=54) in 2022. A periodontist evaluated the periodontal condition of the people, 5 milliliters ofblood sample was taken from participants, gene sequence was determined using the PCR-RFLP method, and statistical analysiswasperformedusing the chi-square testto determine the association between the disease and the mentionedpolymorphism.


64 participants (53.33%) were male, and the rest were female. The frequency of the A allele was 89% in the patient group and 90% in the control group, and the frequency of the G allele was 11% in the patient group and 10% in the control group. Also, the frequency of AA and AG genotypes was 78% and 22% in patients, and 80% and 20% in the control group, respectively (P=0.65).There was no statistically significant association between the genders, the presence of a specific allele or genotype with the occurrence of the disease. The odds ratio (OR) of the developing periodontitis in the heterozygous group compared to the homozygous group was calculated to be0.78% (P=0.65).


 There wasno association between TLR-4 gene polymorphism and chronic periodontitis in the studied population.

Journal of Dental School, Volume:40 Issue: 4, Autumn 2023
159 to 165  
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