Investigationg the impact of profilactic vitamin C on patients pain control after laparoscopic cholecystectomy

Introduction and Problem Statement:

 Acute postoperative pain, especially within the first 24 hours after surgery following the effects of anesthesia drugs, is one of the most significant factors contributing to patient dissatisfaction with their treatment process. Various pharmacological and non-pharmacological methods are being studied to reduce and control postoperative pain. One of the proposed interventions in this regard is the prophylactic intravenous injection of vitamin C. This study aims to investigate the effect of a single intravenous dose of vitamin C administered before surgery on pain control within the first 24 hours after surgery in patients undergoing laparoscopic cholecystectomy.

This study is designed as a clinical trial. Based on this design, 86 randomly selected patients will be divided into two groups: the intervention group, which will receive a single intravenous dose of 1 gram of vitamin C one hour before anesthesia induction, and the control group, which will receive a single intravenous dose of normal saline with the same volume. The pain intensity, nausea, and itching experienced by patients in both groups will be assessed immediately after surgery, 2 hours post-surgery, 6 hours post-surgery, 12 hours post-surgery, and 24 hours post-surgery for comparison.

According to the results obtained, there was no statistically significant difference in the pain levels experienced by patients in both the control and intervention groups at any of the examined time intervals. Additionally, the assessed severity of nausea and itching did not show any statistically significant differences between the two groups at all time intervals.

Based on the results obtained, a single prophylactic dose of vitamin C did not have any significant effect on reducing pain in patients within the first 24 hours after laparoscopic cholecystectomy. This may be due to the small sample size in each group or other confounding factors. Conducting more extensive studies in this field could provide broader insights.