Prognostic significance of tumor location on oncologic outcome of colon cancer

Article Type:
Research/Original Article (دارای رتبه معتبر)

A growing amount of data has indicated the possibility that tumor location may play a prognostic role in colon cancer. The present study set out to investigate the relation between the location of colon cancer (right side vs. left side) and the patient’s oncologic outcome.


In this study, 654 colon cancer patients who had been treated and followed-up at three tertiary hospitals between 2005 and 2014 were included. To determine the most important independent factors of oncologic outcomes, the Cox regression multivariate analysis model used to analyze the prognostic impact of the primary tumor location and other clinical-, pathologic-, and treatment-related factors.


In the univariate analysis, the prognostic factors for disease-free survival (DFS) were the primary tumor stage (< 0.001), node stage (<0.001), tumor grade (P = 0.013), surgical margin status (P = 0.001), lymphatic vascular invasion (LVI) (<0.001), and perineural invasion (PNI) (<0.001). Additionally, the prognostic factors for disease-free survival (OS) were the primary tumor stage (<0.001), node stage (<0.001), tumor grade (P = 0.036), presence of LVI (<0.001), presence of PNI (<0.001), and the mucinous type (P = 0.042). However, in the multivariate analysis, the presence of LVI, T3-4 lesions, tumor grade II-III, and an advanced disease stage remained independent prognostic factors for DFS as well as OS. However, the colon cancer location was not a prognostic factor in terms of DFS or OS.


We didn’t find tumor location as a significant prognostic factor for DFS and OS in colon cancer patients.

Iranian Journal of Colorectal Research, Volume:11 Issue: 2, Jun 2023
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