Batch and Reverse-Flow Injection Spectrophotometric Determination of Hyoscine Butylbromide in Pharmaceutical Formulations

Article Type:
Research/Original Article (دارای رتبه معتبر)
Hyoscine butyl bromide (HBB), also known as scopolamine butyl bromide, is an anticholinergic medication used to treat bladder spasms, renal colic, esophageal spasms, and crampy abdominal pain. A fast and simple spectrophotometric approach is developed for the determination of hyoscine butyl bromide in pure and pharmaceutical formulations using batch and flow injection methods. The proposed approach is based on the reduction of ferrate ion to ferrous ion by HBB and the subsequent formation of excess Fe(III)-thiocyanate complex which gave maximum absorbance at 478 nm. The experimental conditions of both methods for the assay were studied and optimized. The absorbance was found to decrease linearly with the drug concentration to give a calibration curve which obeys Beer’s law in the range of 0.5-200, and 5.0-200 μg/mL with a linear regression coefficient of 0.9964, and 0.9909 with detection limits of 1.40, and 2.10 µg/mL for both batch and rFIA methods, respectively. The proposed approaches were successively applied for the determination of the studied drugs in their different pharmaceutical dosage forms and gave an excellent per cent of recovery compared with the official international pharmacopoeia method.
Chemical Review and Letters, Volume:6 Issue: 2, Spring 2023
105 to 113  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 1,390,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
In order to view content subscription is required

Personal subscription
Subscribe for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!