Hydro-alcoholic extract of Dracocephalum moldavica for treatment of ulcerative colitis in Wistar rats

Message:
Article Type:
Research/Original Article (بدون رتبه معتبر)
Abstract:
Background and objective
The prevalence of ulcerative colitis, a condition characterized by inflammation in the intestinal wall, has been increasing. Dracocephalum moldavica has anti-inflammatory, antioxidant, and immunomodulatory properties. The current study aimed to evaluate the therapeutic effects of Dracocephalum moldavica on ulcerative colitis in Wistar rats.
Materials and methods
Thirty-two male Wistar rats were divided into four groups for this study. Group 1(control) received only phosphate buffer saline, group 2 was exposed to acetic acid to develop ulcerative colitis, group 3 was the rats with ulcerative colitis treated with Dracocephalum moldavica extract at concentration of 30 mg/kg/day, and group 4 was the rats with ulcerative colitis treated by prednisolone at concentration of 4 mg/kg/day. After ten consecutive days, the rats were euthanized humanely, and their intestinal tissue was thoroughly examined to measure the levels of inflammatory mediators and oxidative stress indices.Results and
conclusion
Treatment with Dracocephalum moldavica showed more advantage than treatment with prednisolone in restoring the overall antioxidant capacity of the colonic specimens in rats with induced colitis. Although malondialdehyde levels decreased, the total protein content of colonic homogenates increased in both treatment groups, albeit not significantly. Moreover, Dracocephalum moldavica extract showed a significant reduction in TNF-α, IL-6, and IFNɣ cytokines compared to prednisolone. The stories of myeloperoxidase and nitric oxide were significantly decreased in the colons of rats treated with Dracocephalum Moldavia, surpassing the effects observed in the prednisolone group. The findings of this study suggest that the use of Dracocephalum moldavica extract as an herbal remedy has excellent potential in alleviating inflammation in rat models of ulcerative colitis. The positive roles of Dracocephalum moldavica extract are attributed to its direct antioxidant, anti-inflammatory, and immunomodulatory effects.
Language:
English
Published:
Human, Health and halal Metrics, Volume:4 Issue: 2, Summer-Autumn 2023
Pages:
38 to 47
magiran.com/p2667470  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 1,390,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!