DECREASED EXPRESSION OF MIRNA451 IN THE ENDOMETRIUM OF WOMEN WITH ENDOMETRIOSIS IN THE SECRETORY PHASE OF THE UTERUS

Endometriosis is a chronic and promising yet benign disease in women of reproductive age. Some genetic markers in endometrial have a key effect in the pathogenesis of endometriosis. MicroRNAs are small molecules involved in several biological processes. The aim of this study was to investigate the differential expression of microRNAs, including miRNA451, during the secretory phase in patients with endometriosis.

The present study was conducted as a case-control study. Twenty infertile women with endometriosis who were referred to the Center for Research on Reproductive Health and Infertility of Babol University of Medical Sciences and Fatima Al-Zahra Infertility Specialized Treatment Center in Babol and were diagnosed by sonography or laparoscopy or laparotomy and tissue histology and after exclusion of individuals with other causes of female infertility were included in this study. Also 20 healthy women who had no female factor infertility were selected as the control group. The relative expression levels of mir451 in the endometrium of women in both groups were identified using Real-time PCR.

The mean level of mir451 expression in the endometrium of the endometriosis group was 0.46306 ± 0.71740 and in the control group it was 2.11621 ± 3.32579, which was significantly lower in the endometriosis group (P < 0.001).

The results of this study showed a significant reduction in the expression of mir451 in the endometriosis group compared to the control group. This could be investigated as a potential causative factor or indicator of endometriosis. Therefore, with further studies, it may be possible to use these microRNAs as diagnostic biomarkers for patients with endometriosis.