Synthesis of New Azo Dyes of Uracil via Ecofriendly Method and Evaluation For The Breast, Liver and Lung Cancer Cells In vitro

Article Type:
Research/Original Article (دارای رتبه معتبر)
Uracil derivatives have been the focus of many researchers examining their potential as a cancer-fighting agent. Human breast, liver, and lung cancer cells were used to test the target compounds and compared to cisplatin. There was a wide range of activity in the newly synthesized compounds against breast and lung cancer, but none were effective against liver cancer. Nevertheless, the most effective substances were 4d and 4j, which were quite effective against both kinds of cell lines. It was shown that the 4d compound is more effective against breast cancer than 4a, 4b, and 4c compounds, and 4j showed higher cytotoxic activity than 4e, 4f, and g compounds. We have been told that further research into the toxicity of these potent substances, as well as in-vivo testing, are necessary.
Chemical Review and Letters, Volume:6 Issue: 4, Autumn 2023
442 to 448  
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