Long COVID Effects on Level of Physical Activity and Health-Related Quality of Life in the Post-infection Period: A Cross-sectional Study

Long COVID is a major manifestation of long-lasting symptoms experienced by the survivors of the coronavirus infection that may influence patients’ physical and mental health.

This study aimed to evaluate the association of the physical symptoms of COVID-19 (fatigue, breathlessness, and pain) and the level of physical activity with the physical and mental health of survivors in the post-COVID-19 period.

This was a cross-sectional study conducted on 152 hospitalized and non-hospitalized adults infected with COVID-19 aged between 18 and 65 years at the post-infection period with follow-up times greater than 6 months. Standardized instruments, such as the SF12, International Physical Activity Questionnaire (IPAQ), Multidimensional Fatigue Inventory (MFI-20), and visual analog scale (VAS), were used for measuring pre-and post-COVID-19 painful symptoms, fatigue, and breathlessness. The severity of the coronavirus infection was judged based on hospitalization or ICU admission. Data were analyzed with linear regression analysis.

The results showed that, at a mean duration of 6 months post-discharge, only fatigue was associated with lower physical (F = 2.84, explained variance = 15.3%) and mental health (F = 1.88, explained variance = 10.6%)

Considering the negative impact of fatigue on the physical and mental health of patients during the post-COVID period, it is suggested to monitor and manage fatigue for a longer period post-COVID-19.