Serum Levels of Tripartite Motif-containing Protein 72 (TRIM72) in Iraqi Rheumatoid Arthritis Patients and Its Relevance to the Disease Activity State

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Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background and Objective

 Uncontrolled active rheumatoid arthritis patients have a progressive disability, pain, swelling problems, and stiffness that often lead to systemic complications, early death, socioeconomic costs, and comorbidity. The objectives of this study were to measure the serum levels of Tripartite motif-containing protein 72 in Iraqi patients with rheumatoid arthritis and healthy individuals, assessment of the efficiency of Tripartite motif-containing protein 72, determine their essential serum rates in association with disease activity,  sociodemographic and clinical specifications of the diseases.

Materials and Methods

 In this case-control study, 117 Iraqi patients with rheumatoid arthritis were investigated according to the 2010 American College of Rheumatology / European League Against Rheumatism from December 2020 to March 2022. The patients were divided into two groups. Group 1 were the RA patients with active disease, Group 2 were the RA patients with inactive disease, and healthy subjects served as the control group.

Results

 Serum levels of Tripartite motif-containing protein 72 in the active RA groups (101.92±160.18 Pg/mL) were significantly higher as compared with the inactive RA group (64.58±54.34 Pg/mL) and the control group (41.06 ±32.48 Pg/mL) (P˂0.005). Tripartite motif-containing protein 72 could not discriminate between RA and the controls (since its AUC ≥0.689).

Conclusion

 There was a positive relationship between DAS-28ESR and Tripartite motif-containing protein 72 levels, which induces bone erosion. The serum Tripartite motif-containing protein 72 level showed a significant elevation in rheumatoid arthritis patients compared with healthy controls. Tripartite motif-containing protein 72 had a poor discriminative ability between RA and the control group.

Language:
English
Published:
Journal of Advances in Medical and Biomedical Research, Volume:31 Issue: 149, Nov-Dec 2023
Pages:
602 to 611
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