The Impact of Capecitabine and Combined Training on BRCA1 Gene Expression in Breast Cancer Induction

This study explores the combined effects of concurrent training and capecitabine consumption on breast cancer prevention and therapy, focusing on the modulation of BRCA1 gene expression.

In the main study, 12 mice were divided into groups, including Exercise-Tumor-Exercise (ETE), Exercise-Tumor-Exercise+Drug (ETE + D), and various others. Resistance and endurance training were conducted five days a week for 12 weeks before and eight weeks after tumor induction, accompanied by capecitabine administration. BRCA1 gene expression was assessed post-intervention using SPSS 20.

MC4-L2 injection induced tumors. Both pre and post-cancer induction, exercise significantly increased BRCA1 gene expression (p = 0.001, p = 0.001). Exercise combined with post-cancer capecitabine led to increased BRCA1 expression (p = 0.001). Capecitabine alone post-cancer also elevated BRCA1 expression (p = 0.001). Exercise, exercise with capecitabine, and capecitabine alone post-cancer showed significantly higher BRCA1 expression than exercise pre-cancer (p = 0.001). Exercise-tumor-exercise and Exercise-Tumor-Exercise+Drug groups exhibited increased BRCA1 expression compared to exercise-tumor-drug (p = 0.001).

The ETE+D protocol, involving exercise and capecitabine post-cancer, increased BRCA1 expression, suggesting potential roles in tumor prevention and therapy.