Obstetrics and Fertility Prognosis of Patients With Ovarian Granulosa Cell Tumors: A Retrospective Study in Northwest Iran

Ovarian granulosa cell tumors (GCT) are rare tumors with a late recurrence and a good prognosis. The current study investigated the fertility and obstetrics situation, survival, and the factors influencing the mortality of patients with these uncommon ovarian neoplasms.

This is a retrospective study on ovarian GCT patients admitted to the Al-Zahra hospital oncology department, the tertiary referral hospital in Tabriz, between 2009 and 2022. Data were collected from medical records. Chi-square/Fisher exact tests and t tests were used to compare categorical and quantitative variables between the alive and dead patients, respectively. The Kaplan-Meier curve was used to present patients’ survival.

The study involved 65 patients with ovarian GCT. The presence of ovarian cysts statistically increased the survival of GCT patients (P=0.028). The advanced tumor stage (P=0.023), fast tumor growth (P=0.001), and tumor relapse (P=0.001) are significantly correlated with mortality in the affected patients. However, age and adjuvant chemotherapy were not associated with survival.

There was no evidence of increased survival with the use of adjuvant chemotherapy. Tumor staging is an important prognostic factor. Advanced stages were associated with inferior survival, and only prospective studies can ascertain their definite role.