𝐹𝑖𝑐𝑢𝑠 𝐸𝑙𝑎𝑠𝑡𝑖𝑐𝑎 𝐿- A Potential Antimicrobial Agents: Insight from Experimental and Insilico Approaches

Antibiotic resistance and worries about the use of synthetic drugs have been serious concerns in the scientific community. Researchers are working to develop alternatives to synthetic drug use, and to lessen the negative impact that these drugs have on the systems of the human body. Research indicates that Ficus elastica contains a number of bioactive substances, including flavone, which, when tested on a clinical isolation, had antibacterial activity. In this work, three solvents—ethanol, chloroform, and n-hexane—were used to extract the qualitative phytochemical components, such as alkaloids, tannins, saponins, terpenoids, and phlobatannins. On extracts of Ficus elastica in various solvents, the effects of common antibiotic discs including gentamycin, azithromycin, ciprofloxacin, nitrofurantoin, and ofloxacin were investigated. Ficus elastica crude ethanol, n-hexane, and chloroform extracts were statistically significant when compared to the control and standard antibiotic discs at P<0.001. The most effective crude extract, both in terms of antibacterial action and phytochemical analyzes, is n-hexane. Ficus elastica possesses high antibiotic activity against pathogenic bacterial isolates, according to the current study's findings, and phytochemical analysis revealed that this activity is mediated by substances present as secondary metabolites. Thus, disorders brought on by the test bacterial pathogens can be treated with Ficus elastica extract.