Investigation of Pathological, Etiological Findings, and Ways of Prevention and Treatment in Dengue Fever

Dengue (DEN) virus is a common arboviral infectious disease that poses a significant threat to global public health, putting nearly half of the world's population at risk of infection. It is transmitted by Aedes aegypti and Aedes albopictus mosquitoes. Dengue infection, caused by all four mosquito-borne serotypes (DEN-1 to DEN-4), is endemic in countries with tropical and subtropical climates worldwide. To date, there is no vaccine that provides effective immunity against all DENV serotypes. Additionally, there is limited information regarding the epidemiology and impact of this dangerous disease in regions with recent infection reports. In this study, we aimed to present a summary of the clinical symptoms, pathology, etiology, prevention, and treatment options based on previous studies, to facilitate a better understanding of dengue fever (DF). The results of this study show that the main effects of DF are on vital organs such as the liver (hepatocellular necrosis), lungs (pulmonary edema), kidneys (hematuria and proteinuria), heart (myocarditis), and brain (encephalopathy). These effects can be a major threat to a person's life if diagnosed incorrectly or late. Increasing public awareness through social networks, implementing appropriate waste management systems, removing breeding sites for Aedes aegypti and Aedes albopictus mosquitoes by government institutions, and providing proper laboratory diagnostic and treatment tools for patients with DF are essential solutions that should be prioritized globally.