Pregnancy in Patients with Treated Beta Thalassemia Major in 2 Centers(Ali Asghar Children Hospital & Thalasemia Clinic): Outcome for Mothers and Newborn Infants

Beta thalassemia major is a severe transfusion dependent anemia that causes infertility due to iron deposition to endocrine organs after overtransfusion. Very few pregnancies were reported among such patients in the past. However, after modern therapies, patients who have been receiving a prolong intensive treatment with hyper transfusion and iron chelation become spontaneously pregnants. Patients & The present study was conducted on 32 thalassemia women who were admitted to Ali Asghar children’s Hospital and the Thalassemia Clinic, and were concepted spontaneously. The objective of this cross-sectional study was to estimate the frequency of fertility (spontaneous ovulation or ovulation induction) and complications for mother and newborn including: cardiac failure, endocrinological and hepatic parameters monitored at the beginning, throughout and after pregnancy, viral infection, term and preterm deliveries and complication of pregnancy. All the files were studied and data was analyzed with SPSS software. The checklists were gathered and the findings showed that 12 babies were delivered by elective cesarean section and the others were vaginally delivered. The mean brithweight of the newborns was 2678gr. All babies were normal, 45 cases were mature, 5 of them were preterm, and 12 cases were spontaneous abortion. 27 of mothers had no cardiac problem and 5 of them had cardiac failure. Pregnancy can be safe for mothers and babies, if the women with thalassemia start early intensive treatment.