The Comparison of Frequent Idiopathic Recurrent Abortions Frequency in Consanguineous and Non-Consanguineous Marriages

Spontaneous abortion is referred to the termination of pregnancy prior to 20 weeks of gestational age. Numerous factors have been described which associate with recurrent wastage such as; uterine abnormalities, infections, immunological factors, endocrinologic imbalance, chromosomal and genetic defects. It is accepted that, if a balanced translocation is carried by one of the partners can cause repeated spontaneous abortions as well as autosomal recessive; trait carrier can increase homozygosity, which in turn, leads to an increased risk of abortion. The purpose of this study is to determine the frequency of recurrent abortions in consanguineous marriages in comparison to non-consanguineous marriages. Cytogenetic evaluation of 354 couples with the history of recurrent miscarriages was performed on the basis of G-banning technique. All other possible etiologic factors were excluded. Then 177 couples were grouped in the consanguineous marriage group and the remaining of 177 couples in nonconsanguineous marriage group. Individual characteristics were collected in a questionnaire and analyzed by descriptive statistical chi-Square and Fisher test. The prevalence of state of balanced translocation was found in only 26 partners (7.34%). Among them, 12 individuals (3.38%) appeared in consanguineous group and the remaining 14 partners (3.95%) were seen in non-consanguineous group. The frequency of abortions was significantly more common in women with 2 spontaneous abortions whereas the fewer incidences appeared in women with 10 recurrent miscarriages. On the other hand the numbers of abortions beyond the 3 cases were more prominent in consanguineous group in contrast to the non-consanguineous group. In consanguineous marriages in which recurrent miscarriages are occurring, In the case of normal karyotype, an autosomal recessive disorder could be postulated.