Association between Helicobacter pylori infection with coronary heart disease

Today ischemic heart diseases are the first reason of death in most societies, and in studies done some testimonies have reported about the role of inflammations and chronic infections in the pathogenesis of coronary heart disease. The aim of this study was to find out if there were any association between Helicobacter- pylori infection and atherosclerosis. In this case-control study, endoscopy, urease test, and serology on 164 individuals (82 with coronary heart disease and 82 healthy ones) were performed to test the existence of Helicobacter-pylori. Finally, the obtained data were statistically analysed at the significant level of P≤0.05 by applying SPSS software and t-test. It was found that among 82 individuals in the control group urease test of 82.5% and serology test of 65% were positive and among the case group (82 patients) 75% of urease test and 70% of serology test was positive. There was not a meaningful relationship between infection and coronary heart disease (P=0.21). In these two groups, whose age and gender were partly matched, there was not a meaningful statistical difference with regard to Helicobacter-pylori infection. Thus, other factors (inflammatory and non-inflammatory) for coronary heart disease should be investigated.