Study On the rate of Brucellosis relaps efficiency Different Treatment Protocols in among Hospitalized Patient in Educational Hospital of Hamadan

Brurcellosis is a zoonosis disease that reportdd from every part of the world. Causative agent is an intracellular organism that invades to any organ of human body and produces various clinical infections. Some organisms may escape from different antibiotic effects, causing a re-infection and relapse. In this study, efficiency of different treatment regimes has been compared for the ability to clearance the infection and to prevent from the relapse. In this research, all hospitalized patients from 1994 to 1997 that had brucellosis were studied for relapse. Diagnosis of the brucellosis relepse was based on having brucellosis symptoms during two past years and positive results of serology or culture. In this study, 36 cases of relapse were observed from a total of 542 patients having brucellosis. 22 patients were under treatment by three antibiotic Therapy regimes that relapse was observed only in I case (4.54%). 95.38% of studied patients had treated with two antibiotics therapy. Streptomycin and rifampin shows the highest number of relapse (8.33%), while rifampin and co- trimoxazole is the most successful method among two antibiotics therapies with only 4.78% of relapse rate. This study showed that the rate of relapse not only is acceptable in comparison with other reports, but confirmed rifampin and co-trimoxazole is the most successful regimes. Also three antibiotic therapies do not have an obvious advantages from rifampin and co-trimoxazole