Kinetic disposition, urinary excretion and dosage regimen of subcutaneously administered levofloxacin in cross bred calves
Author(s):
Message:
Abstract:
The present study was conducted on five healthy male cross bred calves to study the kinetic disposition and urinary excretion of levofloxacin following its single subcutaneous administration at the dose of 4 mg.kg-1. The concentration of levofloxacin in plasma and urine samples was estimated by microbiological assay. Peak plasma level of levofloxacin (2.8 ± 0.3 mg.ml-1) was observed at 45 min and the drug level above MIC90 in plasma, was detected up to 12 hrs of administration. The bioavailability of levofloxacin was 41.9 ± 3.2%. High value of AUC (9.88 ± 0.1 mg.ml-1.hr) reflected a vast area of body covered by drug concentration. Good distribution of the drug was reflected by the high value of Vdarea (0.73 ± 0.04 L.kg-1). The elimination half-life and MRT were 3.0 ± 0.2 hr and 4.79 ± 0.2 hr, respectively. A suitable subcutaneous dosage regimen for levofloxacin was calculated to be 1.25 mg.kg-1 repeated at 12-hr intervals in calves.
Language:
Persian
Published:
Iranian Journal of Veterinary Research, Volume:8 Issue:4, 2008
Page:
313
magiran.com/p467949  
روش‌های دسترسی به متن این مطلب
اشتراک شخصی
در سایت عضو شوید و هزینه اشتراک یک‌ساله سایت به مبلغ 300,000ريال را پرداخت کنید. همزمان با برقراری دوره اشتراک بسته دانلود 100 مطلب نیز برای شما فعال خواهد شد!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی همه کاربران به متن مطالب خریداری نمایند!