Cerebral MRI Findings in Neonatal Tuberous Sclerosis

Tuberous sclerosis (TS) is a developmental neuroectodermal disorder, affecting multiple organ systems. Most patients are diagnosed at the age of five years or later. Only recently, mutation analysis of TS Complex genes has enabled us make an early or even an antenatal diagnosis of the disease. Early onset with infantile seizures is mainly an ominous sign for an unfavorable outcome.MRI findings in older children and adults are well-known; however, only limited publications illustrate brain MRI findings in newborns. We present a female neonate with a positive family history, categorized as "definite TS." On MRI of the brain, white matter lesions were depicted. MRI findings were correlated with published data on neonatal TS.