Relationship of Total Homocysteine, Cholesterol, Triglyceride in the Serum and Diastolic Blood Pressure of Patients with Myocardial Infarction

Recent studies have documented the importance of lipids and lipoproteins as determinants of serum total homocysteine concentrations in persons with myocardial infarction, and in healthy subjects. Associations between various biological systems and total homocysteine have also been reported. However, some of these associations are poorly understood. The purpose of our study was to measure serum total homocysteine concentrations in men and women who were selected for health and myocardial infarction to determine the relations of triglycerides, cholesterol and diastolic blood pressure. The study group consisted of 136 patients, 77 male and 59 females, aged 39-73 (mean 46.75 ± 3.91). The control group consisted of 145 normal volunteers, 81 males and 64 females, aged 31-63 (mean 41.72 ± 6.89). Serum total homocysteine was determined by gas chromatograph. Serum cholesterol and triglyceride were measured enzymatically on a spectrophotometer. Our results showed that serum total homocysteine concentrations were significantly positive correlated with cholesterol, triglyceride and diastolic blood pressure. Iran. Biomed. J. 5 (2 & 3): 97-101, 2001