Hormone-Induced Variation of Phosphatidate Phoshohy drolase Activity in Various Tissues of Pregnant Rats

Abstract:

Variations in phosphatidate phosphohydrolase (PAP) activity and triacylglycerol concentration were measured in pregnant and hormone-treated non-pregnant female rats. PAP activity in adipose tissue was elevated by 61% during pregnancy. The increase in the enzyme activity was paralleled with a rise in serum triacylglycerol concentration (44%). Estradiol injecting into non-pregnant rats increased PAP activity of both adipose tissue (19.8%) and the liver (26%). Progesterone also elevated the enzyme activities of adipose tissue and liver by 10% and 55%, respectively. Both hormones increased serum triacylglycerol concentration (20-29%). The data demonstrated that hypertriglyceridemia observed during pregnancy was mediated through the hormonal effects on PAP activity, a key enzyme in glycerolipid metabolism. Iran. Biomed. J. 5 (2 & 3): 103-106, 2001

Language:
English
Published:
Iranian Biomedical Journal, Volume:5 Issue: 2, Jul-Apr 2001
Page:
103
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