The preventive effect of vitamin E on cadmium chloride-induced toxicity in rat liver and kidney
Author(s):
Abstract:
Environmental exposure to cadmium (Cd) occurs via food, occupational industries, terrestrial and aquatic ecosystem. Increasing evidence indicated that Cd induced toxicity in human and animals. However, The mechanism by which its produced toxicity is not completely understood. It has been shown that lipid peroxidation is involved in Cd–related toxicity. Vitamin E is an effective antioxidant and free radical scavenger. The aim of this study is to investigate the preventive effect of vitamin E on cadmium-induced toxicity in rat liver and kidney.
Materials And Methods
Adult NMARI male rats were treated with 5mg/kg vitamin E or corn oil (vehicle) only. 30 min later animals were given Cd Cl (ip) at doses of 0.5,, .5 and mg/kg. The control group received normal saline (vehicle). All animals were treated for 7 consecutive days. 4 hr after last administration all rats were killed with over dose of sodium pentobarbital. The blood was collected for determinations of ALT, AST, ALP, BUN and creatinine. The liver and kidney tissues were removed, fixed and processed for light microscopy, using H&E staining method. CdCl induced dose-dependent injury in both liver and kidney tissues. Statistical analysis showed significant increase all biochemical parameters in CdCl-treated rats when compared to control groups (p>0.05). Vitamin E had no effect on rat liver or kidney. However, this agent protected cells against CdCl toxicity. The results of this study support the view that vitamin E has potential to protect rat liver and kidney tissues against CdCl toxicity.
Language:
Persian
Published:
Jundishapur Scientific Medical Journal, Volume:6 Issue: 4, 2008
Page:
404
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