Relationship of Serum Lipoprotein(a) with Carotid Intimae-Media Thickness in Predialysis Chronic Renal Failure, Hemodialysis and Kidney Transplant Patients.

To evaluate the correlation of lipoprotein(a) with intimae-media thickness of Statistical significance was carotid artery in chronic renal failure patients(CRF), not yet on dialysis, hemodialysis(HD) and kidney transplant patients. One hundred-thirty subjects consisted of (group1) 29 (f =15, m=14) normal healthy persons, (grou2) 33 (f =18, m=15) chronic renal failure not yet on dialysis, (group3) 43 (f =19, m=24) hemodialysis patient and (group4) 25 (f =16, m=9) kidney transplant patients were selected and evaluated for Carotid-intimae-media(IMT) Sonography and cholesterol, Triglyceride, HDL-c, LDL-c and lipoprotein(a) (Lp(a)) as well as BUN and Creatinin measurements. IMT more than 0.8 mm and Lp (a) more than 39 mg/dl (by the kit) were considered abnormal. There was a significant difference between mean of Lp(a) in 4 groups (p=0.016). There was a significant difference between IMT of 4 groups (p<0.001), and significant difference between IMT of CRF patients with HD group (p=0.039).There was a significant correlation between IMT and age in group1 (p=0.035), group2 (p=0.017) and group3 (p=0.019). No association between duration of CRF or the length of the time patients had been on hemodialysis with IMT in groups 2 and 3 was found. In group3 positive correlation of Lp (a) with IMT was found (p=0.045). This study showed positive correlation of lipoprotein (a) with IMT in hemodialysis patients, the age was the most important factor in association with thickening of intimae-media complex in normal, chronic renal failure as well as hemodialysis and kidney transplant groups.