Serum Level of Ox- LDL and Activity of Superoxid Dismutase in Hypertensive Patients

Arterial hypertension is one of the most prevalent diseases, as well as an important risk factor for coronary artery and cardiovascular-induced morbidity and mortality, and end organ damages (such as cerebrovascular disease, renal failure, and congestive heart failure). On the other hand elevated blood pressure and its effect on intensity and velocity of blood flow can increase oxidation and peroxidation reactions. The aim of this study was to evaluate the serum level of Ox-LDL and the activity of superoxid dismutase (SOD) among hypertensive patients. 70 hypertensive patients with no history of CHF, cardiomyopathy, liver disease, diabetus mellitus, renal and thyroid disease, to gether with 70 matched control ones (in terms of gender and age) enrolled in this study. The amount of Ox-LDL and activity of SOD in serum were measured with ELISA and enzymatic colorimetric methods respectively. Data obtained from patients (mean age 52.2±14) and controls (mean age 45±13) showed that the level of SOD activity in patients group was 10027 U/ml, whereas it was 105 11 U/ml in control group. In addition, the level of Ox-LDL in patients and controls group were 14 4 mu/ L, and 7.7 3 mu /L, respectively. We concluded that the elevation of Ox-LDL versus the reduction of SOD activity in hypertensive group might be the result of oxidation processes.