The effect of prenatal restraint stress on the immune function of 60 days male rats
Message:
Abstract:
Background
The role of prenatal restraint stress on the immune function of male rats has been studied previously. In this study we evaluated the effect of this stress on some of the blood cells.
Methods
To study of the prenatal restraint stresses effect on the immune system, pregnant rats were divided into four groups including one control group and three experimental groups. The control group did not receive any stress during the gestation period. In the experimental groups (1, 2 and 3) the pregnant rats were subjected to the restraint stress respectively from 8 to 21, 8 to17, and 17 to 21 days of gestation Offspring were housed in laboratory conditions with their mothers until 40 days of age. At the age of 60 days the blood samples were taken from the male rats.
Findings
Prenatal stress markedly decreased the total number of white blood cells (WBC) in groups 1 and 3, and the percent of granulocyte cells in groups 1, 2 and 3 decreased. The percent of lymphocyte cells in the groups 1, 2 and 3 compared with control group increased significantly. The number of red blood cells (RBC) significantly increased in group 1 and 2 compared to control group. The number of platelet cells also increased in group 1.
Conclusion
Our data support that prenatal restraint stresses alter the function of immune and hemopoietic system. Further studies needed to evaluate these effects precisely.
Language:
Persian
Published:
Journal Of Isfahan Medical School, Volume:26 Issue: 90, 2008
Page:
286
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