Arterial Resistive Index (RI) in Type II Diabetic Nephropathy Stages and Healthy Controls p. 29-32

Background/ Doppler ultrasonography can be an effective method to assessthe severity of diabetic nephropathy. This study was conducted to investigate the relationship between Doppler ultrasound resistive index (RI) values and the clinical andlaboratory findings in patients with diabetic nephropathy.Patients and Doppler ultrasound was performed for 45 patients with type IIdiabetes mellitus and 30 healthy controls. Clinical and laboratory findings of cases andcontrols were also recorded. Diabetic patients were categorized into 3 groups according to the severity oftheir nephropathy, based on the serum creatinine level and 24-hour urine protein. Themean±SD RI was 0.59±0.03 for the control group, 0.67±0.04 for stage I, 0.73±0.02for stage II, and 0.85±0.07 for stage III diabetic nephropathy (p<0.001). RI was significantly associated with the 24-hour urine protein and creatinine (R2=0.75 and =0.67, respectively; p<0.001) and a suitable regression model was adopted to predict the 24- hour urine protein and serum creatinine level based on RI. RI increases with the progression of diabetic nephropathy. RI can be used forestimation of the 24-hour urine protein and serum creatinine and for determining thestage of nephropathy, especially for patients not cooperating for collection of the 24-hour urine protein.