The Relationship between Age, Weight, BMI, Postmenopausal Age and Bone Mineral Density in Post Menopause Women

Osteoporosis is a multifactorial disease and several factors are involved in development and progression of the disease. The aim of this study was to increase our understanding of the relation between age, weight, BMI, postmenopausal age and bone mineral density in post menopause women. 240 Azarbaijani women aged 50-70 years having inclusion criteria were recruited. Bone mineral density (BMD) of lumbar spine (LS), femur neck (FN) and total hip were measured. Based on BMD, all subjects were divided into 3 groups osteoporotic, osteopenic and normal. Personal characteristics of the individuals were obtained and weights and heights were measured. There were significant differences between age, postmenopausal age (PMA), weight and BMI of the 3 study groups (for age, PMA and weight, p<0.001 and for BMI, p=0.018). There were negative correlations between age and PMA and BMD of different skeletal regions. After controlling the confounding variables, the association between age and BMD of hip and FN as well as PMA and BMD of LS remained significant (p=0.003, p<0.001 and p=0.025). There was also a significant correlation between weight and BMI and BMD of the measured skeletal sites. This study confirmed the positive and protective effect of weight and BMI on BMD. It also revealed the negative effect of age and PMA on BMD of different skeletal regions.