Prevelence of Celiac Disease in Patients with Different Types of Dyspepsia

Celiac disease may be presented with dyspepsia. This study was done to evaluate the prevalence of celiac disease and its association with different types of dyspepsia and also the need for duodenal biopsy in patients with non-ulcer dyspepsia.Metods:All patients with dyspepsia were classified as ulcer dyspepsia (duodenal ulcer and gastric ulcer) and non-ulcer dyspepsia (dysmotility-like non-ulcer dyspepsia and ulcer-like non-ulcer dyspepsia). Distal duodenal biopsy was done for all patients. Then, specific serologic factors for celiac disease (Anti-Gliadin Antibody and tissue Transglutamines Antibody) were checked in patients with villous atrophy. Finally, the prevalence of celiac disease and its association with different types of dyspepsia were evaluated.

Of the 810 patients with dyspepsia, 703 had non-ulcer dyspepsia and 107 had peptic ulcer. Six (5.6%) of the patients with peptic ulcer and 54 (7.7%) of patients with non-ulcer dyspepsia had villous atrophy and positive Anti-Gliadin Antibody or tissue Transglutamines compatible with celiac disease, but there was no significant deference between celiac disease and different types of dyspepsia (P > 0.05). In non-ulcer dyspepsia, odds ratio for Celiac disease was 1.4, in comparison with the peptic ulcer

During endoscopic examination for non-ulcer dyspepsia, if indicated, endoscopists should carefully inspect the duodenum for CD findings. Although, routine serologic screening can not be recommended; it may be appropriate for the patients with refractory dyspepsia.