Serum human chorionic gonadotropin as a predictor of outcome in assisted reproductive technology pregnancies

Message:
Abstract:
Objective
Assisted reproduction treatment (ART) entails a risk of ectopic pregnancy and early pregnancy loss. Serum ß-human chorionic gonadoropin (ß-hcg) has been found to be predictive of pregnancy outcome. Our aim was to determine whether serum ß-hcg levels obtained 16 days after ovulation are reliable predictors of pregnancy outcome. Subjects and
Methods
In this retrospective study, 200 women who have achieved a pregnancy through ART treatment at the infertility clinic of Mashhad Medical Sciences University were evaluated. The treatment included IUI in 196 (98%), ICSI in 2 (1%) and IVF in 2 (1%). Serum samples were obtained on days 16 and serum ß-hcg concentration was measured by immune-radiometric assay.
Results
The mean age at treatment was 29 (range 19–35 y). One hundred and sixty women aged above 30 y and 40 cases aged below 30 y. Out of 200 patients with ART cycles 175 cases were found to be viable pregnancies (live fetus at 20 weeks gestation) and 25 patients resulting in spontaneous abortion. A statistically significant difference was found between the mean ß-hcg value of the non-viable and viable pregnancies (P<0.001).
Conclusions
A single serum ß-hcg level 16 days after ovulation provides a useful predictor of pregnancy outcome.
Language:
English
Published:
Jundishapur Scientific Medical Journal, Volume:8 Issue: 1, 2009
Page:
10
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