Tetanus antitoxin levels and cutaneous anergy in hemodialysis patients in two university hospitals in Iran
Message:
Abstract:
Background
The global incidence of tetanus is about 1 million cases annually. Tetanus antibody values decrease with age. Some patients with humoral immune deficiencies may not respond adequately to tetanus toxoid vaccination. The incidence of infectious disease is increased in patients with chronic renal failure. The purpose of this study was to determine tetanus antitoxin level and cutaneous anergy test in hemodialysis patients.
Materials And Methods
A cross sectional study was performed on 44 hemodialysis patients who had been on dialysis thrice a week for at least 2 months. Quantitation of tetanus-specific antibodies was achieved by ELISA technique. Then, for Manteaux test 0.1ml of 1/10 saline diluted solution of tetanus and diphtheria toxoid was injected intradermally to the volar surface of the shunt-free arm. Induration was recorded 48-72h and 7-9 days after the injection.
Results
Twenty-eight (64%) patients had induration ≤5mm in 48-72h, classified as non-responsive, whereas 16 (36%) had induration ≥5mm that was classified as positive test (NS). There was no significant correlation between age, sex, duration of dialysis, frequencies of dialysis, history of tetanus-diphtheria vaccination and cutaneous anergy test. Of 44 patients, 34(77.3%) had antibody level of
Language:
English
Published:
Archives of Clinical Infectious Diseases, Volume:1 Issue: 1, Jan 2006
Page:
31
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