Gastrointestinal and Liver Malignancies after Renal Transplantation: A Multicenter Study

Immunosuppression increases the incidence of cancer and promotes the growth of neoplasm in kidney transplant recipients. There have been few reports on the incidence of gastrointestinal (GI) and liver cancers from transplant registries.
In the current study, we collected data from 8 kidney transplant centers in Iran between 1984 and 2008, to detect the incidence, type, and outcome of GI and liver cancers after kidney transplantation. Only histologically confirmed tumors that occurred after renal transplantation were included in the analysis. We also compared their data with 3028 kidney recipients of two transplant centers.
50 years of age) and the total time on immunosuppression. Patient and graft survival rates from the time of GI and liver cancers onset were poor.
CRC was the most common GI tumor following kidney transplantation and was predominant in male. GI and liver malignancies have poor prognosis and early diagnosis and prompt treatment of the post- transplant malignancies is essential.