Monoclonal Antibodies, A Brief Review of Production and Applications

In the 1950, Lederberg and Talmage observed that each clone of B-lymphocytes produces one type of antibody, so antibodies should have a monoclonality nature. 25 years later, in the 1975, Knhler and Kilstein used hybridation of corresponding cells to produce monoclonal antibodies (McAb). Today monoclonal antibody is belived as a powerful tool for diagnosis and treatment and too many other purposes in the biologic sciences specially medicine. The aim of this review article i''s to describe some aspects of McAb production and application.