Correlation between histological findings, activity & choronicity indices and laboratory data in patients with lupus nephritis
Message:
Abstract:
Background
Renal involvement in systemic lupus erythematosus (SLE) is one of the most serious complications. Numerous reports have documented the unpredictable course of lupus nephritis and the role of renal biopsy in evaluation of individual patients. It is impossible to predict the types, severity and activity of renal lesions based only on combination of clinical and laboratory findings.
Objective
The aim of this study was to evaluate the histological findings, activity and chronicity scores, and also assessing the correlation between histology and other laboratory findings in patients with lupus nephritis.
Methods
This cross-sectional study was carried out on 40 patients with diagnosis of lupus nephritis at Ghaem Hospital in Mashhad during 2003 to 2006. Renal biopsy was performed for all patients and correlation between laboratory and serologic parameters and the histological findings were investigated. Data were analyzed using t-test, Chi square test, and Fischer exact test.
Findings
Activity score was 9.02 in 34 patients with proteinuria and 6.33 in 6 patients without proteinuria (p=0.018). There was a significant correlation between the activity score and serum C4 levels (p=0.031). Also, a significant correlation was shown between fibrous crescent (one of the chronicity criteria on biopsy) and nephrotic syndrome (p=0.047). No significant correlation between activity and chronicity scores and other laboratory and serologic findings was found.
Conclusion
Based on our data, no exact correlation between histological findings and laboratory data in lupus nephritis was demonstrated therefore, emphasis on important role of renal biopsy in evaluation of these patients is suggested.
Language:
Persian
Published:
Journal of Inflammatory Diseases, Volume:14 Issue: 1, 2010
Page:
5
magiran.com/p718535  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!