Prevalence of Gestational Trophoblastic Disease and Relative Factors

Gestational trophoblastic disease (GTD) is one of the rare neoplastic diseases that remains curable even with a lot of metastases, but if left untreated, it can be life threatening. We had an increase in number of GTD during recent years in Ahvaz. The aim of this study was to determine the prevalence and risk factors of trophoblastic diseases among women who were admitted in Imam Khomaini Hospital, Ahvaz, Iran. Subjects and In this cross-sectional study, all hospital records related to trophoblastic diseases (n=132) were reviewed from 1996 up to 2006. Demographic and histo-pathologic data were taken using a questionnaire containing 34 questions. The Chi-square, "t" and Exact -Fisher tests were used to analyze all data. P≤ 0.05 was considered significant statistically. SPSS, version 11 was used for statistical analysis.The prevalence of hydatidiform mole was 5.4 in 1000 deliveries including 81.8% complete and 18.1% incomplete moles. It was shown that 34.2% of complete moles turned to persistent forms out of which 6.4% changed into invasive moles and 2.7% into choriocarcinoma. There was a significant association between complete and persistent moles and more than 40 years of age (p<0.02), but there was not any association between incomplete moles and increased age. There was a significant correlation between blood group of women (A and O) and complete moles (p<0.05). Pregnancy in the older ages and lack of follow-up of molar patients after suction-curettage is an important factor in the prevalence of hydatidiform and persistent moles.