Assessement of reproductive toxicity induced by deltamethrin in male albino rats
Abstract:
Introduction
Pyrethroids are important insecticides because of their high activity and low mammalian toxicity. Some studies have demonstrated that these insecticides, especially compounds with an -cyano group, produce toxic effects on various biological systems. Deltamethrin (DTM) is a Type II synthetic pyrethroid insecticide containing -cyano group and is used worldwide in agriculture, home pest control, protection of foodstuff, and disease vector control. In this study, the toxic effects of DTM were evaluated in adult male albino rats.
Material and Methods
Treated groups were given DTM orally at various dose levels (7.5, 17.5 and 27.5mg/kg b. wt./day for 45 days) with a positive control group-receiving vehicle (olive oil) only and their fertility rate and male sex organs were evaluated.
Results
Signs of toxicity and reduction in the weight of testes and accessory sex organs were observed in a dose-dependent manner. DTM brought about marked reduction in epididymal and testicular sperm counts and fertility in insecticide-exposed males. A significant decrease in the sialic acid content of testes, epididymis, ventral prostate, seminal vesicle and testicular glycogen was noticed. However, the cholesterol and protein content of testes and accessory sex organs was raised significantly in all treated groups. A significant reduction in seminal vesicle fructose and serum testosterone was also observed after DTM administration. Histopathological examination revealed severe degenerative changes in seminiferous tubules while these effects were milder at the lowest dose level.
Conclusion
These results provide first hand information that DTM adversely affects the reproductive system of male rats.
Language:
English
Published:
Iranian Journal of Toxicology, Volume:2 Issue: 3, Autumn 2009
Page:
194
magiran.com/p754573  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!