Evaluation of Leptin and Adiponectin Levels in Patients with Stable Angina Pectoris

Leptin and adiponectin are two adipose tissue hormones, whose association with the incidence of cardiovascular diseases is under evaluation. The aim of this study is to determine the relationship between leptin and adiponectin, and coronary artery diseases. 170 patients with angina and indications of coronary angiography underwent angiography. Moreover, serum level of blood lipids, leptin, and adiponectin were measured. The gathered data was evaluated using SPSS software, V. 15, by multivariate variance analysis. Analysis of the data demonstrated that 45.1% of the patients had positive angiographic findings. The serum levels of leptin and adiponectin were significantly lower than the minimum level specified by the kit. However, the two groups, i.e., patients with positive angiographic findings and those with negative findings were not significantly different according to the serum levels of the hormones. Moreover, no significant correlation between the serum levels of the hormones and serum lipids was observed. Various studies have demonstrated that high serum level of leptin and the incidence of coronary artery diseases are correlated. On the other hand, they have reported adiponectin to have cardioprotective role. Confirmation of these findings requires more detailed studies.