ANTINOCICEPTIVE EFFECT OF BACLOFEN IN ALLOXAN-INDUCED DIABETIC MICE.

To evaluate the effect of hyperglycemia on the antinociceptive activity of baclofen, a GABAB agonist, in mice. We examined the antinociceptive effect of baclofen (2.5-7.5mg/kg injected intraperitoneally) in alloxan-induced mice using the hot-plate and tail-flick tests, both thermal tests. Baclofen produced a dose-dependent inhibition of hot-plate response in both normoglycemic and diabetic mice. The antinociceptive activity of baclofen was slightly reduced in diabetic mice. In comparison, the antinociceptive activity of morphine (10mg/kg), used as control, was significantly reduced in diabetic mice. Our results show that hyperglycemia reduces the antinociceptive action of baclofen less than it does that of morphine.