Comparative Study of Unna's Boot and Betamethasone Cream in Treatment of Sulfur Mustard-related Pruritus

Pruritus, a chronic symptom caused by Sulfur Mustard, is a common problem among veterans. Numerous treatments like anti-histamines, local anesthetics and corticosteroids have been prescribed in order to control pruritus in these patients, while long term and widespread use of each one has its own restrictions. Nowadays different mixtures including Unna`s Boot, are being used. They are effective and have limited adverse effects. So in this study we compared this product with corticosteroids. In this double-blind randomized clinical trial in Baqiyatallah (a.s.) hospital, 90 veterans were included and randomly divided into three groups. Subjects of each group received one of the Betamethasone 1%, Unna`s Boot or placebo creams for three weeks. They used their medication on an itching area of body, one finger tip unit every night. To evaluate the drugs` efficacy we used pruritus score and (Visual Analysis Score) VAS indecies. Results. From 90 patients, 75 patients completely used the medication and the rest 15 subjects, excluded from the study. All three drugs caused significant decrease in both pruritus and visual analysis score indecies (P<0.001). Betamethasone and Unna`s Boot were significantly more effective than placebo and despite more efficacy of betamethasone rather than Unna`s Boot, they did not have any significant difference (P>0.05). Pruritus is a chronic symptom in veterans which needs long time symptomatic treatment. Regarding definite side effects of local long term therapy with corticosteroids and nearly equal efficacy of Unna`s Boot and betamethasone, Unna`s Boot seems to be a better choice in controlling Sulfur Mustard-related pruritus.